This publication will document the fourth cycle review and appraisal of the implementation of the Madrid International Plan of Action and its Regional Implementation Strategy (MIPAA/RIS, 2002) in UNECE member States between 2017 and 2022. The regional review will conclude with the 5th UNECE Ministerial Conference on Ageing to be held in Rome, Italy, in May 2022 (tbc). The Conference Proceedings aim to support the work done by policy makers, researchers, and civil society by providing an overview of where we stand today and of the challenges that need attention.