The Sustainable Development Goal 6 Synthesis Report 2023 is the UN family’s “flagship” report at the midterm review of the SDGs. It offers a strategic guide to accelerating progress on SDG 6 and delivering on the outcomes of the UN 2023 Water Conference, including the Water Action Agenda. The report summarizes the global water crisis and progress on SDG 6 at the halfway point of Agenda 2030. It conveys UN-Water’s vision for the second part of the 2030 Agenda and presents actionable policy recommendations to Member States on how to achieve SDG 6 by 2030 by using the SDG 6 Global Acceleration Framework. This includes how water policy and governance can interact with other SDGs for greater impact, and communicates how the UN system can support the implementation of the second half of the “Water Action Decade” and the Water Action Agenda. The report calls for improved coordination and cooperation between all relevant stakeholders, including Member States, to accelerate progress on SDG 6 as part of a cross-sectoral and integrated approach to effectively manage water and sanitation for the entire sustainable development agenda. The report will contribute to the discussions of Member States and relevant stakeholders at the In-depth review of SDG 6 during the 2023 High-level Political Forum on Sustainable Development and SDG Summit 2023.